DEVELOPMENT AND EVALAUTION OF LORATADINE GEL FOR TRANSDERMAL DRUG DELIVERY

Authors

  • Zakia Faculty of Biological, Pharmaceutical and Health Sciences, University of Balochistan, Pakistan
  • Dr. Rahman Gul Faculty of Biological, Pharmaceutical and Health Sciences, University of Balochistan, Pakistan
  • Dr. Syed Umer Jan Faculty of Biological, Pharmaceutical and Health Sciences, University of Balochistan, Pakistan
  • Abdul Ghaffar Faculty of Biological, Pharmaceutical and Health Sciences, University of Balochistan, Pakistan
  • Falsafa Jamal Community Medicine department Bolan Medical College, Quetta, Balochistan, Pakistan
  • Kashmala Khan Fatima Jinnah Medical University Lahore, Pakistan
  • Hafsa Gharsheen Federal Medical College Islamabad, Pakistan
  • Isra Durrani Biotechnological. Agriculture Research Institute & Cooperative Department Government of Balochistan, Pakistan

DOI:

https://doi.org/10.63163/jpehss.v3i2.314

Abstract

Abstract

Objective:

This research was conducted to develop and evaluate sustained release topical gels containing Loratadine, olive oil used as penetration enhancer with various concentrations to see its effect on drug release concentration.

Method

Several gel formulations were prepared using hydrophilic polymers including Carbopol 940, to investigate their impact on drug release characteristics and physicochemical properties. The formulations were assessed for pH, spreadability, viscosity, drug content, and in vitro release profile. The study used sophisticated advanced techniques including Diffraction (XRD) Scanning Electron Microscopy (SEM) and Transform Infrared Spectroscopy (FTIR) to examine the physicochemical properties of the gel. Franz diffusion cells were employed for release studies, and the release kinetics were interpreted using multiple mathematical models.

Results

Physicochemical evaluation were pretty smooth and homogeneous with pH values ranging from 5.2 to 6.3, drug content uniformity fell within acceptable limits ranging roughly from 97.10% to 98.19% across formulations. Optimized gel released nearly 76.93%.Increase in olive oil concentration increase in permeability. Release kinetics conformed remarkably well to First order. FTIR spectroscopy confirmed chemical stability of Loratadine in gel. XRD analysis revealed Loratadine crystalline peaks diminished in final gel. SEM images revealed a remarkably smooth surface devoid of visible crystalline drug particles indicating homogeneous distribution and efficient entrapment of drug

Conclusion

Indicated that Carbopol gels provided optimal sustained release and acceptable physicochemical characteristics, supporting their potential use for transdermal delivery of Loratadine.

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Published

2025-05-07

How to Cite

Zakia, Dr. Rahman Gul, Dr. Syed Umer Jan, Abdul Ghaffar, Falsafa Jamal, Kashmala Khan, Hafsa Gharsheen, & Isra Durrani. (2025). DEVELOPMENT AND EVALAUTION OF LORATADINE GEL FOR TRANSDERMAL DRUG DELIVERY. Physical Education, Health and Social Sciences, 3(2), 506–513. https://doi.org/10.63163/jpehss.v3i2.314