Formulation, Evaluation of Naproxen and Dexpanthenol Emulgel for TransdermalDrug Delivery

Abstract

Objective: The aim of this study was to formulate emulgel of naproxen and dexpanthenol, a NSAID and complex of B vitamin, utilizing Carbapol 940 as a gelling agent. Mineral oil and clove oil were used as penetration enhancers. Methodology: In the first step emulsion was developed and it was added in gel base. Formulations were assessed for pH, viscosity, spread ability, conductivity, Homogeneity, drug content, FTIR, XRD, SEM, in-vitro drug release and stability studies were conducted. Results: The formulations characteristics showed improved and stable results. F6 showed higher released rate as compared to others formulations, FTIR and XRD confirmed compatibility and stable physical states, while SEM revealed a uniform surface. In-vitro studies indicated a sustained drug release profile suitable for transdermal delivery. Conclusion: It can be concluded that the naproxen-dexpanthenol emulgel demonstrated likely as an effective transdermal drug delivery system. Its stability, enhanced release, and possible physicochemical characteristics showed a promising option for treating inflammatory skin conditions