Investigation of Antioxidant Compounds in Ginger (Zingiber Officinale) for Cancer Treatment

Abstract

Antioxidants, which eliminate reactive oxygen species (free radicals), are present in a wide range of food items and are generally known as scavengers. Antioxidants are crucial for maintaining human health as the body's natural defensive mechanisms are unable to function properly when exposed to excessive oxygen stress. Among herbs and spicy Ginger (Zingiber officinale Roscoe) extract and its components have anti-proliferative activity, anti-inflammatory, antioxidant and best as chemo-preventive agent. Prior research on in vitro examinations of ginger formulations and certain isolated components revealed that ginger exhibits anti-inflammatory properties, including the inhibition of Cox and the inhibition of nuclear factor KB. Additionally, it triggers apoptosis in endometrial cancer cells by activating P53. The aim of this study is to find components of ginger which lay path to overcome or kill Cancerian cells, avoiding chemo or radiation-based methods of curing. The Phenolic compounds were extracted utilizing methanol, Ethanol, Chloroform and ethyl acetate. High performance liquid chromatography (HPLC) is used to analyze the compound 2, 2-diphenyl-1, picrylhydrazyl (DPPH). Phenolic compounds were then analyzed utilizing HPLC and DPPH array. This result shows ginger extract have number of anti-oxidants, which can further be used for cancer treatment. The purpose of this paper is to study the anti-oxidant and anticancer compounds in the extract of Zingiber officinale for cancer research. Simultaneously, these results illustrate that ginger extract has vigorous anticancer activity against cancer.