Investigation and Validation of Selected Herbal Formulations for Claimed Antidiarrheal Activity

Authors

  • Salimullah Khan* Department of Pharmacy, Abdul Wali Khan University Mardan, Pakistan, KP, Pakistan.
  • Fawad Ahmad Department of Pharmacy, Abdul Wali Khan University Mardan, Pakistan, KP, Pakistan
  • Atta Ullah Department of Biotechnology, Abdul Wali Khan University Mardan, Pakistan
  • Muhamma Aizaz Department of Biotechnology, Abdul Wali Khan University Mardan, Pakistan
  • Aneela Iqbal Department of Biotechnology, Abdul Wali Khan University Mardan, Pakistan
  • Syeda Andleeb Hussain Department of Biotechnology, Abdul Wali Khan University Mardan, Pakistan
  • Syed Muhamad Shafi Shah Department of Biotechnology, Abdul Wali Khan University Mardan, Pakistan
  • Razaullah Khan Soil Science Laboratory, National Agriculture Research Council (NARC), Islamabad, Pakistan

DOI:

https://doi.org/10.63163/jpehss.v3i2.420

Keywords:

Sharbat Habb-ul-Aas, Rooh-e-Kafoor, Loperamide, Anti-diarrheal, Charcoal

Abstract

Sharbat Habb-ul-Aas and Rooh-e-Kafoor syrups are the two branded herbal formulations marketed widely in Pakistan for their antidiarrheal properties. This study is focused to validate the antidiarrheal potential of both products and to provide experimental evidence for their use. Selected products were investigated against different types of diarrhea induced by castor oil (1 ml/kg), magnesium sulphate (2 mg/kg) and clarithromycin (100 mg/kg) using pigeon model. Change in GI transit time was also determined using charcoal activity. Both products demonstrated significant reduction in average weight of stool and reduction in intestinal motility. Excellent anti-diarrheal activity demonstrated by the products may be due to different crude drugs included in the formulations. These findings revealed that use of Sharbat Habb-ul-Aas and Rooh-e-Kafoor syrups for the control of diarrhea is justified and may be effective as alternative medicine for the control of diarrhea.

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Published

2025-05-27

How to Cite

Salimullah Khan*, Fawad Ahmad, Atta Ullah, Muhamma Aizaz, Aneela Iqbal, Syeda Andleeb Hussain, Syed Muhamad Shafi Shah, & Razaullah Khan. (2025). Investigation and Validation of Selected Herbal Formulations for Claimed Antidiarrheal Activity. Physical Education, Health and Social Sciences, 3(2), 350–357. https://doi.org/10.63163/jpehss.v3i2.420

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